Fly to Panama

There are currently a few ways to fly to Panama from Europe or America. Here are a few options for you:

From Europe

The current best way to fly from any European country today would be using KLM. KLM flies direct to Panama from Amsterdam. Check your local travel agency for a correct rate.
Direct flights from Amsterdam every day at 11:15 CET and arrives in Panama 16:30 (local time)
Should you want to pass over America, there is a couple of options available. Copa, Delta, Continental, American Airlines and Copa all fly direct from USA to Panama. It is however not recommended as the total flight using KLM is 16 hours, where going over America will take you more than 20 hours.

From America

The major airlines that flies direct from America to Panama are:
American Airlines, Continental, Copa, Delta, Mexicana, Taca and Sprint.
Here are their local American airports locations having direct flights to Panama:
New York (Copa & Delta)
Newark (Continental)
Washington DC (Copa)
Miami (American, Copa)
Los Angeles (Copa)
Houston (Continental)
Dallas (American)
Orlando (Copa)
Fort Lauderdale (Spirit)